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Monthly Archives: May 2022

  • Antimicrobial Peptides: Exploring the Mechanisms of Action

    Antimicrobial peptides, or AMPs, refer to a heterogeneous class of compounds present in a variety of organisms, including human beings. Over the years, the compounds have been isolated and successfully characterized. They have been described in a variety of ways, based on their characteristics, structures, and activities. Mostly, they have been described as natural microbicides with selective toxicity toward bacteria and minimal cytotoxicity towards the mammalian cells of the host organism.
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  • Peptide Therapeutics: Emerging Peptide Areas and Technologies

    It is estimated that the total number of naturally occurring peptides that have been successfully identified is about 7000. These peptides play a crucial role in human physiology including acting as growth factors, neurotransmitters, anti-infective, ion channel ligands, and hormones. Generally, peptides are very selective and highly effective signaling molecules that have the ability to bind to specific cell surface receptors where they may trigger a variety of intracellular effects.
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  • Peptides in Cancer Research: Therapies and Vaccines

    Cancer refers to the uncontrolled division of cells and the ability of those cells to attack cells in neighboring organs to form tumor masses before spreading to other parts of the body. Although angiogenesis, or the development of new blood vessels from existing blood vessels, is a vital process for growth and development, it is also one of the steps used by tumors in transitioning from a tumor-dormant state to a malignant state. Therefore, one of the processes that have been explored in suppressing the growth of tumor cells is the smart use of angiogenesis inhibitors.
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  • Antimicrobial Peptides’ Applications in the Treatment of Liver Cancer

    Antimicrobial peptides can be found in almost all species of plants, invertebrates and vertebrates. Most of the already identified antimicrobial peptides feature less than 100 amino acid residues as well as a myriad of common features, the most notable ones being hydrophobicity, amphipathic structure, and cationicity. The peptides can be found inducibly or constitutively in a variety of tissue and organs that witness constant exposure to microbial pathogens like the cells in the epithelial tissues of the skin, the respiratory tracts, and the gastrointestinal lining. Antimicrobial peptides display a wide range of antimicrobial activities against fungi, bacteria, viruses and protozoa. Presently, they have been heavily studied and their uses in the treatment of multi-drug resistant pathogens have been well-documented.
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