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Monthly Archives: December 2021

  • Antimicrobial Peptides: Classification, Design, and Applications

    Antimicrobial peptides, also known as AMPs, are heterogeneous compounds present in various organisms including human beings. Currently, there are hundreds of antimicrobial peptides which have been isolated and properly characterized. They can be thought of as natural microbicides with the ability to selectively cytotoxic bacteria, while at the same time doing minimal harm or damage to the mammalian cells of the host organism.
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  • Most Desirable Benefits and Pharmacological Properties of Bioactive Peptides

    Bioactive peptides, or BP, refer to specific protein fragments that have a positive impact on a variety of body functions and may influence one's health in a number of ways. Presently, it is estimated that there are more than 1500 bioactive peptides, and these are well documented in a database known as Biopep. You can also think of bioactive peptides as organic substances that arise when amino acids are joined by covalent bonds known as amide or peptide bonds.
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  • ❄️⛄️ Happy Holidays 2021 from Canada Peptide ⛄️❄️

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  • Tumor Homing Peptides: Advanced Application in Cancer Therapies

    Currently, there is an increase in the focus on “precision medicine” in oncology, a term used to refer to advanced modes of treatments or therapies. Most of the time, the term is used to indicate very particular tumor therapies that utilize antitumor agents with the capability of working in a gene-specific manner, to deliver an antitumor payload to a specific cell or tissue with the help of a compound delivery system technology.

    There are various types of recently developed small molecule inhibitors which have been proven to have the ability to inactivate kinase-involved signaling pathways and which represent a group of very specific antibody medications and antibody-compound conjugates (ADC). These ADCs are suggested to possess certain therapeutic effects by having the ability to precisely regulate the dynamics of the compound in vivo, making the efficient accumulation of the payload at target cells by binding the conjugated antibody to very specific cell surface antigens.
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  • Current Strategies for Enhancing the Bioavailability of Food Peptides

    Food peptides are being viewed as vital ingredients of functional foods, as well as nutraceuticals that could be used to promote good health, and lower the risks of getting certain types of chronic illnesses. But, though it has been shown that peptides have a variety of health benefits, including the ability to assert multiple benefits by chemical assays, animal models, and cell culture, it has been an arduous and time-consuming task to translate the new findings into commercial or practical applications.
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  • Structural Analysis Techniques for Membrane Peptides

    There are various biophysical techniques used for determining both the secondary and tertiary structures of membrane peptides, in order to understand the mechanism of their uptake, as well as their actions on the membranes.

    The methods are mainly used to investigate the peptide’s orientation relative to their thermodynamic properties, and their binding abilities. Currently, it has been reported that there are 313 AMP structures present in the Protein Data Bank – PDB. In this piece, we will explore the various methodologies that were applied in the determination of these, and other structures that have been established so far.
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  • Current Strategies Being Utilized to Improve Bioavailability of Food Peptides

    One of the greatest obstacles in overcoming the challenges associated with the bioavailability of food peptides, has always been a lack of knowledge or adequate results in studies involving the mechanisms through which bioactive peptides are transported.

    With clearer knowledge about the mechanisms involved in the transportation of bioactive peptides, as well as clear insights into the factors that affect their absorption, it becomes relatively easy for scientists to come up with various strategies to enhance the bioavailability of the peptides, and also how to maintain their potency in in vivo. This is because the scientist will have a clearer picture of what they need to overcome in order to make the peptides more bioavailable.
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  • What You Need to Know About the Current State of Absorption of Food Peptides

    The absorption of most of the digested foods usually takes place in the jejunum. This is normally where the chyme enters from the stomach, pending it being broken down to its constituent nutrients, which are then taken into systemic circulation across the walls of the small intestines. For a very long time, the traditional belief was that once a peptide is ingested, through the processes of digestion, the peptides could be broken down by the digestive enzymes into their constituent amino acids, which could then be easily assimilated through the epithelial cells of the small intestines.
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  • Food Derived Bioactive Peptides and the Human Health

    The physiochemical functions of proteins in food are continuously being appreciated by many. In addition to their dietary benefits, several studies continue to reveal that they have more to offer than just nourishing the body. Many of the physiochemical functions of most of the naturally occurring proteins are through the actions of peptide sequences that have been encrypted inside the parent proteins. Bioactive peptides refer to peptide sequences within a protein with beneficial activities on various body functions and have the ability to impact human health beyond its known nutritional benefits. Bioactive peptides have the ability to regulate vital body functions through a variety of activities, including antimicrobial, immunomodulatory, and antioxidant, antithrombotic, and mineral binding functions.
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  • Everything You Need To Know About Bioactive Peptides

    Bioactive Peptides, simply known as BP, refer to certain specific protein segments that display positive impacts on certain body functions or conditions that may ultimately impact health. At the moment, it is believed that there are over 1500 bioactive peptides that have already been reported in the Biopep Database – the database dedicated to keeping the records of all discovered bioactive peptides in the world. Bioactive peptides can also be viewed as organic substances formed by amino acids which have been joined by covalent bonds.
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