Monthly Archives: January 2021

Cell-penetrating peptides, also known as CPP, have the ability to cross plasma membranes. Ever since the discovery of this ability, it has been exploited for a variety of applications, including delivering bioactive molecules to stop the actions of diseases producing cellular mechanisms.

Through the selective delivery of drugs into the target cells, it is possible to achieve improved drug distribution, as well as a significant reduction of dosing and toxicity. In this review, we will look at some of the challenges being encountered in this specific field of application, as well as some of the factors that may influence the efficacy of the delivery.
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The presence of large-scale manufacturing and advanced synthesis technologies have currently made it possible for the production of even the most complex peptide anti-infectives.

With the possibility of this class of molecules being seen as the next-gen of infectives, safe anti-microbial, as well as with a better understanding of pharmacology and biology, it is just a matter of time before we see the introduction into clinical trials for these promising drug candidates.

This is a vital step in the history and life cycle of peptide anti-infectives and it is one of the strongest indications that the therapeutic and commercial potential of the anti-infectives, is about to be achieved.
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