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Monthly Archives: December 2020

  • The Development and Use of Peptides as Therapeutics

    Peptides refer to biologically active molecules that contain at least two amino acids, interlinked by a peptide bond. Unlike large proteins, they are small in size and a typical chain will usually not go past 100 amino acids.

    Since peptides are highly selective and also known to have relatively safe characteristics, their pharmacological profiles have always appealed to the research world. They are readily available in the human body where they play diverse biological roles.

    For most applications, they mainly act as regulatory and signaling molecules in various physiological processes. Back in the day, the instability of peptides limited their use in the design and development of human drugs, but due to technological breakthroughs, the instability challenges have all been overcome, greatly increasing the broad application of peptides.
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  • The Use of Therapeutic Peptides in Cancer Treatments

    Cancer and cardiovascular diseases are among the major causes of death in most developed countries. Most of the conventional approaches to treating cancer are quickly losing their therapeutic relevance due to the lack of tumor selectivity, drug resistance, and solubility. As such, there is a great need for the development of new therapeutic agents and treatment plans. Over the years, therapeutic peptides have provided a glimmer of hope, and they are currently being considered as a novel approach to treating a variety of diseases, including various forms of cancer.

    This is because they come with a variety of advantages over normal proteins and antibodies. Some of these advantages include easy synthesis, high target selectivity, and specificity, and very low toxicity. They, however, have some drawbacks, with their stability and short half-life being among major concerns. In this piece, we will be looking at some of the therapeutic peptides receiving the most attention currently and some of the strategies being used to overcome some of the peptide limitations.
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  • Promising Cancer Therapies With Peptide-Based Treatments

    Peptides are molecules consisting of various chains of amino acids joined by peptide bonds through the process of a dehydration-condensation reaction. There are various places, or various origins of peptides, including but not limited to direct synthesis by the body, artificial synthesis, or through processes such as proteolysis. They play a huge role in the treatment of a variety of diseases, and they are currently at the center stage in the development of various types of vaccines.

    Diseases such as allergic reactions, asthma, fibrosis, autoimmune diseases, and infectious diseases have been some of the greatest beneficiaries of peptide-based therapies. There are several advantages that make peptide therapies preferred in the treatment of a variety of diseases. Some of these benefits include the fact that they are easily available, easy to purify and store. Some of the therapies have undergone both in vitro and in vivo testing, with a lot of promising outcomes. There are also several studies continuing to look into how peptides can be used as effective therapies for a variety of conditions.
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  • Interesting Findings About Peptide Immunotherapeutics

    The development of peptide vaccines has been in the works for a very long time, but with minimal success. However, advancement in medical technology, as well as an increased understanding of the immune system – more specifically the operations of the antigenic epitopes in stimulating an immune response, have opened a whole new field and made the development of peptide vaccines possible. Peptide-based vaccines – technically known as epitope ensemble vaccines, are viewed as a viable alternative approach to the discovery and development of not just disease-specific therapeutics but also prophylactic vaccines.

    These vaccines are very different from the other types of vaccines or moieties, which usually use dead or attenuated whole pathogens in the formulation of the vaccines. With this approach, epitopes are viewed as the relevant parts of the antigens commonly referred to as B and/or T cells mediating adaptive immunity. As such, the most promising epitope vaccine ensemble is those that feature desirable B and T cell-mediated immune responses. Also, with peptide-based vaccines, the risks of starting a pathogenic reaction or other undesirable off-target responses are much lower compared to the conventional vaccines. This, hence, brings a lot of credence to these vaccines are they are seen to be safer and more effective compared to the conventional vaccines.
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  • Peptides as Therapeutic Agents for Inflammatory-Related Diseases

    An inflammation is the body's normal response to lesions and infections. The immune system cells move to the site of the injury or infection, and cause an inflammation. To treat this disorder, unspecific small molecule drugs are used, which may cause some side effects.
    The inflammation produces mediators such as cytokines, interleukins, and growth factors. It is necessary to regulate the inflammation to stabilize or heal the damaged cells or tissues.

    A lot of research is being made, and peptides have been used as an alternative anti-inflammatory therapy. Actually, peptides are considered effective compounds, and show an innovative strategy by stopping, diminishing, and/or changing the expression and activity of mediators.
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  • What are the benefits of peptides in cosmetics ?

    The cosmetic industry represents a huge worldwide sector. Between skincare, makeup, and haircare, it is growing faster than most other industries, and its market value is estimated to be worth almost $805 billion by 2023.

    The key to this evolution is innovation. Every brand tries to create new products with new compositions in order to target a maximum of people. More and more people are very careful about each product’s contents, which is why brands always have to conduct lots of research and find a way to make the perfect product, containing the best natural elements possible.
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  • ❄️⛄️ Happy Holidays 2020 from Canada Peptide ⛄️❄️

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  • Antimicrobial Peptides in Human Health

    The human body has always been special to scientists because it has this amazing capacity to repair itself (like a broken bone) and to protect itself from any kind of exterior aggressions. After studies and a lot of research, it was discovered that peptides in the body are one of the reasons why it can face pathogens and stay healthy.

    One kind of peptide is very important in the body, which is the antimicrobial peptide (AMP). These peptides are essential to the body's natural defense against diseases. They ward off invading microbial pathogens such as viruses and bacteria. Also, they have had a major role in the development of therapeutic agents to prevent and treat diseases, which has become even more important, considering the situation we are facing now.
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  • The Potential of Antifungal Peptides as Therapeutic Agents

    Fungi have been used for centuries for food and beverage processing. In recent years, a better understanding of science and advancement in medical technology has shone a spotlight on their potential of being used as antibiotics to overcome the well-known deficits of the current antibiotics in use. However, it should not be forgotten that fungi are also responsible for causing a myriad of human infections. There is well-documented evidence of an increase in the number of cases for community-acquired fungal infections over the last decade.

    Also, a rise in the number of immunodeficiency-related cases, antibiotic resistance development, and limited therapeutic options have made the search for alternatives a serious concern, and one which the research world is currently heavily involved with. There is a need for the new antifungals being formulated currently to be less toxic for the host, and it is also vital for them to have broader or targeted antimicrobial spectra, and have very little chances for triggering resistance in the long run.
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  • What You Need To Know About Antimicrobial Peptides

    The presence of various natural antimicrobial substances that contribute to a horde of body defense mechanisms was discovered during the late 19th century, and the research world has never rested since then. It was in the year 1963 when in vitro antimicrobial activities of leukocyte extracts was discovered to be an activity of basic proteins. Since then, there have been discoveries of various cationic peptides with antimicrobial properties. Most of these peptides were discovered in host cells and tissues and virtually in every other living species.
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